Peripheral Neuropathic Facial/Trigeminal Pain and RANTES/CCL5 in Jawbone Cavitation
Identifieur interne : 002C47 ( Pmc/Curation ); précédent : 002C46; suivant : 002C48Peripheral Neuropathic Facial/Trigeminal Pain and RANTES/CCL5 in Jawbone Cavitation
Auteurs : Johann Lechner [Allemagne] ; Volker Von Baehr [Allemagne]Source :
- Evidence-based Complementary and Alternative Medicine : eCAM [ 1741-427X ] ; 2015.
Abstract
Url:
DOI: 10.1155/2015/582520
PubMed: 26170877
PubMed Central: 4481083
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Peripheral Neuropathic Facial/Trigeminal Pain and RANTES/CCL5 in Jawbone Cavitation</title>
<author><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Clinic for Integrative Dentistry, Gruenwalder Strasse 10A, 81547 Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinic for Integrative Dentistry, Gruenwalder Strasse 10A, 81547 Munich</wicri:regionArea>
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<author><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Medical Diagnostics-MVZ GbR, Nicolaistrasse 22, 12247 Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Medical Diagnostics-MVZ GbR, Nicolaistrasse 22, 12247 Berlin</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Peripheral Neuropathic Facial/Trigeminal Pain and RANTES/CCL5 in Jawbone Cavitation</title>
<author><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Clinic for Integrative Dentistry, Gruenwalder Strasse 10A, 81547 Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinic for Integrative Dentistry, Gruenwalder Strasse 10A, 81547 Munich</wicri:regionArea>
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</author>
<author><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Medical Diagnostics-MVZ GbR, Nicolaistrasse 22, 12247 Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Medical Diagnostics-MVZ GbR, Nicolaistrasse 22, 12247 Berlin</wicri:regionArea>
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<series><title level="j">Evidence-based Complementary and Alternative Medicine : eCAM</title>
<idno type="ISSN">1741-427X</idno>
<idno type="eISSN">1741-4288</idno>
<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><p><italic>Introduction</italic>
. In this study, we elucidate the possible causative role of chronic subclinical inflammation in jawbone of patients with atypical facial pain (AFP) and trigeminal neuralgia (TRN) in the local overexpression of the chemokine regulated on activation and normal T-cell expressed and secreted (RANTES/C-C motif ligand 5 CCL5). Neurons contain opioid receptors that transmit antipain reactions in the peripheral and central nervous system. Proinflammatory chemokines like RANTES/CCL5 desensitize <italic>μ</italic>
-opioid receptors in the periphery sensory neurons and it has been suggested that RANTES modifies the nociceptive reaction. <italic>Materials and Methods</italic>
. In 15 patients with AFP/TRN, we examined fatty degenerated jawbone (FDOJ) samples for the expression of seven cytokines by multiplex analysis and compared these results with healthy jawbones. <italic>Results</italic>
. Each of these medullary jawbone samples exhibited RANTES as the only highly overexpressed cytokine. The FDOJ cohort with AFP/TRN showed a mean 30-fold overexpression of RANTES compared to healthy jawbones. <italic>Conclusions</italic>
. To the best of our knowledge, no other research has identified RANTES overexpression in silent inflamed jawbones as a possible cause for AFP/TRN. Thus, we hypothesize that the surgical clearing of FDOJ might diminish RANTES signaling pathways in neurons and contribute to resolving chronic neurological pain in AFP/TRN patients.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Evid Based Complement Alternat Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Evid Based Complement Alternat Med</journal-id>
<journal-id journal-id-type="publisher-id">ECAM</journal-id>
<journal-title-group><journal-title>Evidence-based Complementary and Alternative Medicine : eCAM</journal-title>
</journal-title-group>
<issn pub-type="ppub">1741-427X</issn>
<issn pub-type="epub">1741-4288</issn>
<publisher><publisher-name>Hindawi Publishing Corporation</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26170877</article-id>
<article-id pub-id-type="pmc">4481083</article-id>
<article-id pub-id-type="doi">10.1155/2015/582520</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Peripheral Neuropathic Facial/Trigeminal Pain and RANTES/CCL5 in Jawbone Cavitation</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lechner</surname>
<given-names>Johann</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>von Baehr</surname>
<given-names>Volker</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
</contrib>
</contrib-group>
<aff id="I1"><sup>1</sup>
Clinic for Integrative Dentistry, Gruenwalder Strasse 10A, 81547 Munich, Germany</aff>
<aff id="I2"><sup>2</sup>
Medical Diagnostics-MVZ GbR, Nicolaistrasse 22, 12247 Berlin, Germany</aff>
<author-notes><corresp id="cor1">*Johann Lechner: <email>drlechner@aol.com</email>
</corresp>
<fn fn-type="other"><p>Academic Editor: Haroon Khan</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>11</day>
<month>6</month>
<year>2015</year>
</pub-date>
<volume>2015</volume>
<elocation-id>582520</elocation-id>
<history><date date-type="received"><day>28</day>
<month>9</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>1</day>
<month>4</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015 J. Lechner and V. von Baehr.</copyright-statement>
<copyright-year>2015</copyright-year>
<license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p><italic>Introduction</italic>
. In this study, we elucidate the possible causative role of chronic subclinical inflammation in jawbone of patients with atypical facial pain (AFP) and trigeminal neuralgia (TRN) in the local overexpression of the chemokine regulated on activation and normal T-cell expressed and secreted (RANTES/C-C motif ligand 5 CCL5). Neurons contain opioid receptors that transmit antipain reactions in the peripheral and central nervous system. Proinflammatory chemokines like RANTES/CCL5 desensitize <italic>μ</italic>
-opioid receptors in the periphery sensory neurons and it has been suggested that RANTES modifies the nociceptive reaction. <italic>Materials and Methods</italic>
. In 15 patients with AFP/TRN, we examined fatty degenerated jawbone (FDOJ) samples for the expression of seven cytokines by multiplex analysis and compared these results with healthy jawbones. <italic>Results</italic>
. Each of these medullary jawbone samples exhibited RANTES as the only highly overexpressed cytokine. The FDOJ cohort with AFP/TRN showed a mean 30-fold overexpression of RANTES compared to healthy jawbones. <italic>Conclusions</italic>
. To the best of our knowledge, no other research has identified RANTES overexpression in silent inflamed jawbones as a possible cause for AFP/TRN. Thus, we hypothesize that the surgical clearing of FDOJ might diminish RANTES signaling pathways in neurons and contribute to resolving chronic neurological pain in AFP/TRN patients.</p>
</abstract>
</article-meta>
</front>
<floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>FDOJ sample of fatty and osteolytic degenerated bone marrow (a) and contrast medium X-ray of the FDOJ cavity after curettage (b).</p>
</caption>
<graphic xlink:href="ECAM2015-582520.001"></graphic>
</fig>
<fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>Analysis of seven cytokines in the FDOJ AFP/TRN cohort (<italic>n</italic>
= 15) compared to healthy jawbones.</p>
</caption>
<graphic xlink:href="ECAM2015-582520.002"></graphic>
</fig>
<fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label>
<caption><p>Curettage of FDOJ in the lower jaw with denuded infra-alveolar nerve. Corresponding X-ray without any signs of pathological process in jawbone (b).</p>
</caption>
<graphic xlink:href="ECAM2015-582520.003"></graphic>
</fig>
<fig id="fig4" orientation="portrait" position="float"><label>Figure 4</label>
<caption><p>Mean time of AFP/TRN (45 months), the pain-free period after FDOJ curettage (21 months), and the overall percentage of pain relief (88%).</p>
</caption>
<graphic xlink:href="ECAM2015-582520.004"></graphic>
</fig>
<fig id="fig5" orientation="portrait" position="float"><label>Figure 5</label>
<caption><p>Percentage of pain reduction in the AFP/TRN cohort (<italic>n</italic>
= 15).</p>
</caption>
<graphic xlink:href="ECAM2015-582520.005"></graphic>
</fig>
<fig id="fig6" orientation="portrait" position="float"><label>Figure 6</label>
<caption><p>A patient with AFP in the left upper jaw with overexpression of RANTES/CCL5 in the painful area. The corresponding X-ray marked in red is inconspicuous; pain relief after FDOJ surgery was 90%.</p>
</caption>
<graphic xlink:href="ECAM2015-582520.006"></graphic>
</fig>
<table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label>
<caption><p>Pathohistological findings from FDOJ samples in 15 patients with AFP/TRN.</p>
</caption>
<table frame="hsides" rules="groups"><tbody><tr><td align="left" rowspan="1" colspan="1">AFP/TRN</td>
<td align="center" rowspan="1" colspan="1">15</td>
<td align="center" rowspan="1" colspan="1">100%</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Ischemia</td>
<td align="center" rowspan="1" colspan="1">13</td>
<td align="center" rowspan="1" colspan="1">87%</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Necrotic adipocytes</td>
<td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">67%</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Myxoid degeneration </td>
<td align="center" rowspan="1" colspan="1">12</td>
<td align="center" rowspan="1" colspan="1">80%</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Increased fat cells</td>
<td align="center" rowspan="1" colspan="1">12</td>
<td align="center" rowspan="1" colspan="1">80%</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Inflammatory cells</td>
<td align="center" rowspan="1" colspan="1">1</td>
<td align="center" rowspan="1" colspan="1">7%</td>
</tr>
</tbody>
</table>
</table-wrap>
</floats-group>
</pmc>
</record>
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